I've been using Adobe's Source Code Pro font for reading *literature*, since I may not be aware of a font better matching my preferences — dotted (preferred) or slashed zero, optimized distinct characters (and the letter cases), prominent punctuation marks, most importantly. As a downside, I can't easily tell the difference between the hyphen and em dash (- and —), wondering whether a compound word was used or the latter dash to indicate a pause.
https://github.com/adobe-fonts/source-code-pro/ https://en.wikipedia.org/wiki/Source_Code_Pro
I have a 27'' 4K display and may upgrade to 6K or 8K soon enough (you can count how comparatively high pixel densities even budget smartphones have, on their tiny screens).
I mostly read fiction, but for the occasional programming book the Adobe's sans-serif typeface is invaluable. I don't currently use a serif font and ignore the publisher-set defaults in ebooks.